Claire Foy, Thandie Newton and Charlie Brooker were among the British winners at the 70th Primetime Emmy Awards.
Foy won the best actress in a drama series for her role as Queen Elizabeth II in Netflix’s royal epic The Crown.
Welsh actor Matthew Rhys also took home one of the night’s big prizes – best leading actor in a drama series.
However, two hotly-tipped shows – Atlanta and The Handmaid’s Tale – failed to replicate their successes from last year and went home empty-handed.
Elisabeth Moss had been the pre-show favourite to win best drama actress for the second season of The Handmaid’s Tale, but lost out to Foy.
In her acceptance speech, the British star described her time on The Crown as “the most extraordinary two-and-a-half years of my life”.
She said: “I was given a role I never thought I would ever get a chance to play, and I met people who I will love for ever and ever.
“And the show goes on, which makes me so proud. So I dedicate this to the next cast, the next generation, and I also dedicate this to [her co-star] Matt Smith.”
Olivia Colman is due to take over the role from Foy as the show enters its third season. Stephen Daldry won best directing for a drama series for The Crown.
Newton was awarded best supporting actress in a drama series for her role in Westworld.
“I don’t even believe in God but I’m going to thank her tonight,” the actress said as she took to the stage to collect her trophy.
Rhys picked up best leading actor in a drama series for his role in The Americans.
Set in suburban Washington DC shortly after Ronald Reagan is elected president, the series tells the story of two KGB spies in an arranged marriage who are posing as Americans.
Henry Winkler won his first Emmy – supporting actor in a comedy series for his role in Barry – 42 years after he was first nominated for playing The Fonz in Happy Days.
“Skip Brittenham said to me a long time ago, ‘If you stay at the table long enough, the chips come to you,’ and tonight I got to clear the table,” he said in his acceptance speech.
Biggest Emmy winners (including Creative Arts awards)
Game of Thrones – 9
Saturday Night Live – 8
The Marvelous Mrs Maisel – 8
The Assassination of Gianni Versace: American Crime Story – 7
Anthony Bourdain: Parts Unknown – 5
Jesus Christ Superstar Live In Concert – 5
RuPaul’s Drag Race – 5
The Crown – 5
Jeff Daniels took home the prize for best supporting actor in a limited series or a television movie for his role in Netflix’s Godless – described as a feminist western.
In addition to his family and co-workers, Daniels thanked the streaming service for “letting artists be artists”.
He added: “Little tip for you young actors – when they call and say ‘Can you ride a horse?’ don’t lie. You will find on day one that you’re in the Kentucky Derby.”